47612
Sigma
Folinic acid calcium salt hydrate
BioChemika, ≥99.0% (HPLC)
| Synonym: | 5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt, 5-HCO-H4PteGlu, Calcium folinate, Citrovorum factor calcium salt, Leucovorin calcium salt, 5-Formyl-5,6,7,8-tetrahydropteroyl- |
| CAS Number: | 1492-18-8 (anhydrous) |
| Linear Formula: | C20H21CaN7O7 · xH2O |
| Molecular Weight: | 511.50 (anhydrous basis) |
| Beilstein Registry Number: | 5723924 |
| EC Number: | 216-082-8 |
| PubChem Substance ID: | 24871209 |
Description
| Application | Calcium folinate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer. |
| General description | Calcium salt of the (6R,S)-mixture of diastereomers of 5-formyl-5,6,7,8-tetrahydrofolate. |
| Other Notes | Review1 |
Properties
| product line | BioChemika |
| assay | ≥99.0% (HPLC) |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 36/37/38-42/43 |
| Safety Statements | 26-36 |
| WGK Germany | 2 |
| RTECS | MA0600500 |
References
| Cited Reference | 1. L.O. Pont et al. Anal. Profiles Drug Subst. 8, 315, (1979) |
